EFFECT OF THE ALKYL CHAIN-LENGTH ON THE ANTI-HIV EFFICIENCY OF PRONUCLEOTIDES BEARING S-ACYL-THIOALKYL PHOSPHATE PROTECTING GROUPS

Authors
EGRON D PERIGAUD C GOSSELIN G AUBERTIN AM IMBACH JL
Citation
D. Egron et al., EFFECT OF THE ALKYL CHAIN-LENGTH ON THE ANTI-HIV EFFICIENCY OF PRONUCLEOTIDES BEARING S-ACYL-THIOALKYL PHOSPHATE PROTECTING GROUPS, Bulletin des Societes chimiques belges, 106(7-8), 1997, pp. 461-466
Citations number
16
Categorie Soggetti
Chemistry
Journal title
Bulletin des Societes chimiques belges → ACNP
ISSN journal
00379646
Volume
106
Issue
7-8
Year of publication
1997
Pages
461 - 466
Database
ISI
SICI code
0037-9646(1997)106:7-8<461:EOTACO>2.0.ZU;2-I
Abstract
The synthesis and the anti-HIV activity of two mononucleoside phosphot riester derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) and 2',3' -dideoxyadenosine (ddA) are reported. These compounds incorporate a ne w kind of phosphate-protecting group, namely S-pivaloyl-4-thiobutyl (t BuSATB).