Mycobacterium paratuberculosis commonly infects dairy cattle, leading
to Johne's disease, which is also known as paratuberculosis. The infec
tion is chronic, progressive, and incurable. As the infection progress
es, excretion of M. paratuberculosis in feces and milk occurs, and the
bacterium spreads through the blood to multiple internal organs. Cons
equently, raw products originating from cattle may harbor M. paratuber
culosis. Thermal treatments, such as pasteurization, are commonly reli
ed on to kill foodborne bacterial pathogens that can infect humans. Th
e small number of studies conducted to determine the thermal resistanc
e of M. paratuberculosis suggest that it is less susceptible to destru
ction by heat killing than are milkborne zoonotic bacterial pathogens
such as Listeria spp. or Mycobacterium bovis. Published reports concer
ning the thermal resistance of M. paratuberculosis in milk are reviewe
d herein, and key issues concerning the efficacy of pasteurization for
elimination of M. paratuberculosis from milk are summarized.