TOXICITY OF ALIPHATIC-AMINES - STRUCTURE-ACTIVITY RELATIONSHIP

SARs may enable the evaluation of the toxic potential of chemicals by drawing conclusions from available data on structurally-related chemic als, thus reducing the need for further testing. The Advisory Committe e on Existing Chemicals of Environmental Relevance (BUA) [1,2] of the German Chemical Society (Gesellschaft Deutscher Chemiker [GDCh]) has c ompiled data on the toxicity and ecological impact for several groups of chemicals [3, 4]. In the present review, some common toxicological properties for aliphatic amines were revealed after evaluation and com parison of the toxicity data. (C) 1997 Elsevier Science Ltd.