A newly developed nonparametric multipoint linkage analysis (NPL) by K
ruglyak et al. [1996] was applied to the data set from the Johns Hopki
ns Bipolar Study available through the GAW10 workshop. Our results fro
m GENEHUNTER do not support the analyses of Stine et al. [1995]. Some
possible extensions to incorporate unaffecteds are also discussed. (C)
1997 Wiley-Liss, Inc.