GAW10 - SIMULATED FAMILY DATA FOR A COMMON OLIGOGENIC DISEASE WITH QUANTITATIVE RISK-FACTORS

GAW10 Problem 2 involves a simulated common disease defined by imposin g a threshold, T, on a quantitative trait, Q1. Every individual with a value of Q1 greater than or equal to T (where T = 40) is defined as a ffected. Also thought to be associated with the disease as intervening variables are four other quantitative traits (Q2, Q3, Q4, and Q5) and an environmental factor (EF). Each individual has genotypes for 367 h ighly polymorphic markers on 10 chromosomes. The tasks for GAW10 were to characterize the genetic and environmental contribution to Q1 (and the disease), Q2, Q3, Q4, and Q5, and to localize any single genes tha t have detectable effects. Multiple replicates provided an opportunity to address questions of power and false positive rates. (C) 1997 Wile y-Liss, Inc.