A MULTIVARIATE APPROACH TO AFFECTED-SIB-PAIR ANALYSIS USING HIGHLY DENSE MOLECULAR MAPS

Authors
BAILEY JN PALMER CGS WOODWARD JA SMALLEY SL
Citation
Jn. Bailey et al., A MULTIVARIATE APPROACH TO AFFECTED-SIB-PAIR ANALYSIS USING HIGHLY DENSE MOLECULAR MAPS, Genetic epidemiology, 14(6), 1997, pp. 761-766
Citations number
4
Categorie Soggetti
Genetics & Heredity","Public, Environmental & Occupation Heath
Journal title
Genetic epidemiology → ACNP
ISSN journal
07410395
Volume
14
Issue
6
Year of publication
1997
Pages
761 - 766
Database
ISI
SICI code
0741-0395(1997)14:6<761:AMATAA>2.0.ZU;2-P
Abstract
A multivariate approach to affected-sib-pair analyses was performed to localize disease-susceptibility genes with a minimum number of type I errors (false positives). Using 1,155 independent affected sib pairs extracted from Problem 2A of the GAW10 data set, we were able to local ize major genes (MG) 1 and 2. Using 30% of the affected-sib-pair sampl e (N = 337) we were able to localize MG1. False positives were not det ected in either of these samples. (C) 1997 Wiley-Liss, Inc.