GENOME SCREENING USING EXTREMELY DISCORDANT AND EXTREMELY CONCORDANT PAIRS

We applied extreme sib-pair methods in two ways to the GAW10 Problem 2 A data sets to detect susceptible quantitative trait loci using extrem ely discordant sib pairs only, and combining them with the available e xtremely concordant sib pairs as suggested by the authors elsewhere. T en successive original replicates were combined into one sampling pool so as to get the necessary number of extreme sib pairs. A total of 10 0 replicates were used to produce 10 such data sets for both initial d etection and confirmations. Strong signals were found with markers D5G 15 for Q1, D8G27-28 for 44, and D9G7-9 for Q5. (C) 1997 Wiley-Liss, In c.