A MULTIVARIATE MODEL FOR THE ANALYSIS OF SIBSHIP COVARIANCE STRUCTUREUSING MARKER INFORMATION AND MULTIPLE QUANTITATIVE TRAITS

Authors
VOGLER GP TANG WH NELSON TL HOFER SM GRANT JD TARANTINO LM FERNANDEZ JR
Citation
Gp. Vogler et al., A MULTIVARIATE MODEL FOR THE ANALYSIS OF SIBSHIP COVARIANCE STRUCTUREUSING MARKER INFORMATION AND MULTIPLE QUANTITATIVE TRAITS, Genetic epidemiology, 14(6), 1997, pp. 921-926
Citations number
6
Categorie Soggetti
Genetics & Heredity","Public, Environmental & Occupation Heath
Journal title
Genetic epidemiology → ACNP
ISSN journal
07410395
Volume
14
Issue
6
Year of publication
1997
Pages
921 - 926
Database
ISI
SICI code
0741-0395(1997)14:6<921:AMMFTA>2.0.ZU;2-9
Abstract
A model was developed to detect effects of quantitative trait loci (QT Ls) in sibships from simulated nuclear family data using the full cova riance structure of the data and analyzing all five quantitative trait s simultaneously in a multivariate model. Evidence of the presence of loci was detected on chromosomes 4, 8, 9, and 10. The method provided stable results and is worth further exploration for its performance an d optimal sample size requirements under realistic conditions. (C) 199 7 Wiley-Liss, Inc.