FACTORS INFLUENCING THE IDENTIFICATION OF MAJOR GENES IN A COMPLEX DISEASE GENOME SCAN

Authors
YANG HY WANG YP GOLDSTEIN DR LI ZM VORA H CANTOR RM
Citation
Hy. Yang et al., FACTORS INFLUENCING THE IDENTIFICATION OF MAJOR GENES IN A COMPLEX DISEASE GENOME SCAN, Genetic epidemiology, 14(6), 1997, pp. 933-938
Citations number
6
Categorie Soggetti
Genetics & Heredity","Public, Environmental & Occupation Heath
Journal title
Genetic epidemiology → ACNP
ISSN journal
07410395
Volume
14
Issue
6
Year of publication
1997
Pages
933 - 938
Database
ISI
SICI code
0741-0395(1997)14:6<933:FITIOM>2.0.ZU;2-1
Abstract
A two-stage linkage strategy was employed to identify major genes for a simulated complex disease via a genome scan. The importance of sever al approaches for improving the ability to locate major genes has been illustrated. These approaches are: adjusting for covariates, ascertai ning through multiple affected family members, increasing the sample s ize, and using multipoint linkage analysis. (C) 1997 Wiley-Liss, Inc.