DETECTING GENE-ENVIRONMENT INTERACTIONS USING A CASE-CONTROL DESIGN

Authors
GOLDSTEIN AM FALK RT KORCZAK JF LUBIN JH
Citation
Am. Goldstein et al., DETECTING GENE-ENVIRONMENT INTERACTIONS USING A CASE-CONTROL DESIGN, Genetic epidemiology, 14(6), 1997, pp. 1085-1089
Citations number
10
Categorie Soggetti
Genetics & Heredity","Public, Environmental & Occupation Heath
Journal title
Genetic epidemiology → ACNP
ISSN journal
07410395
Volume
14
Issue
6
Year of publication
1997
Pages
1085 - 1089
Database
ISI
SICI code
0741-0395(1997)14:6<1085:DGIUAC>2.0.ZU;2-J
Abstract
We assessed the sample size required for detecting gene-environment (G x E) interactions in a case-control study of complex diseases. The re sults suggest that large numbers of cases and controls will be require d to detect G x E interaction for some odds ratio and exposure frequen cy combinations. These and other results suggest that alternative stud y designs may be needed to detect G x E interaction particularly with rare genes or uncommon environmental exposures. (C) 1997 Wiley-Liss, I nc.