AFFECTED SIB-PAIR TESTS FOR LINKAGE - TYPE-I ERRORS WITH DEPENDENT SIB-PAIRS

Authors
MEUNIER F PHILIPPI A MARTINEZ M DEMENAIS F
Citation
F. Meunier et al., AFFECTED SIB-PAIR TESTS FOR LINKAGE - TYPE-I ERRORS WITH DEPENDENT SIB-PAIRS, Genetic epidemiology, 14(6), 1997, pp. 1107-1111
Citations number
10
Categorie Soggetti
Genetics & Heredity","Public, Environmental & Occupation Heath
Journal title
Genetic epidemiology → ACNP
ISSN journal
07410395
Volume
14
Issue
6
Year of publication
1997
Pages
1107 - 1111
Database
ISI
SICI code
0741-0395(1997)14:6<1107:ASTFL->2.0.ZU;2-W
Abstract
We compared the robustness of affected-sib-pair (ASP) tests for multip le-affected sibships. Forming all possible pairs increases the type I errors only slightly whereas the most used weighting procedures decrea se the efficiency of the tests. Another weighting procedure accounting for the reduction of variance of the weighted identical by descent (I BD) information appears robust. Missing parental marker data leads to a decrease of type I errors in all cases. (C) 1997 Wiley-Liss, Inc.