GENOMIC SHARING SURROUNDING ALLELES IDENTICAL BY DESCENT - EFFECTS OFGENETIC DRIFT AND POPULATION-GROWTH

Authors
MEERMAN GJT VANDERMEULEN MA
Citation
Gjt. Meerman et Ma. Vandermeulen, GENOMIC SHARING SURROUNDING ALLELES IDENTICAL BY DESCENT - EFFECTS OFGENETIC DRIFT AND POPULATION-GROWTH, Genetic epidemiology, 14(6), 1997, pp. 1125-1130
Citations number
13
Categorie Soggetti
Genetics & Heredity","Public, Environmental & Occupation Heath
Journal title
Genetic epidemiology → ACNP
ISSN journal
07410395
Volume
14
Issue
6
Year of publication
1997
Pages
1125 - 1130
Database
ISI
SICI code
0741-0395(1997)14:6<1125:GSSAIB>2.0.ZU;2-5
Abstract
The number of identical deleterious mutations present in a population may become very large, depending on the combined effect of genetic dri ft, population growth and limited negative selection. The distribution of the length of the shared area between two random chromosomes carry ing the mutations has been investigated for a number of generations va rying from 20-100 since introduction. The consequences for investigati ons using association and haplotype sharing methods are discussed. (C) 1997 Wiley-Liss, Inc.