MODULATION OF SECONDARY ANTIBODY-RESPONSE IN SRBC-IMMUNIZED MICE BY LYSOZYME DIMER

The effect of lysozyme dimer (20 mu g/kg) injected i.p. once or four t imes to sheep erythrocytes-immunized mice on the secondary humoral res ponse was studied with respect to the time of exposure to the drug in relation to priming and challenge. It has been found that lysozyme dim er potentiates secondary humoral response to SRBC; as a result, the nu mber of splenocytes producing hemolytic anti-SRBC antibodies (PFC) and anti-SRBC hemagglutinin titers, especially 2-mercaptoethanol resistan t increases provided that the drug is administered after the challenge . Lysozyme dimer (both a single dose and four times' exposure to the d rug) administered after priming does not affect secondary humoral resp onse of SRBC-immunized mice.