HEMATOPOIETIC CHANGES IN RATS AFTER INESCAPABLE AND ESCAPABLE SHOCKS

Bone marrow cell responsiveness to hematopoietic growth factors was in vestigated in rats only confined or experiencing inescapable, escapabl e shocks or no electric shock. The results demonstrated a significant reduction in the number of granulocyte-macrophage precursors in the bo ne marrow of confined rats and of rats exposed to inescapable shocks. The reversibility of this mielossupressive response was seen in both g roups and occurred first in the confined animals. No changes were obse rved in the group submitted to escapable shocks when compared to contr ols.