PSYCHOTROPIC-DRUGS AND LOCAL-ANESTHETICS RESTORE CARDIOLIPIN-INHIBITED MAMMALIAN DNA TOPOISOMERASE-I ACTIVITY

Authors
SHAH GH KATAOKA K UENO A OHTSUKA Y MIZUSHIMA T SEKIMIZU K
Citation
Gh. Shah et al., PSYCHOTROPIC-DRUGS AND LOCAL-ANESTHETICS RESTORE CARDIOLIPIN-INHIBITED MAMMALIAN DNA TOPOISOMERASE-I ACTIVITY, Biological & pharmaceutical bulletin, 20(12), 1997, pp. 1233-1234
Citations number
8
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
20
Issue
12
Year of publication
1997
Pages
1233 - 1234
Database
ISI
SICI code
0918-6158(1997)20:12<1233:PALRC>2.0.ZU;2-I
Abstract
The activity of mammalian topoisomerase I is inhibited by acidic phosp holipids. We investigated the effect of psychotropic drugs and local a nesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I ac tivity, Chlorpromazine, promethazine, and imipramine, which interact w ith phospholipids, suppressed the inhibitory effect of cardiolipin, Th e present results suggest that relaxation of DNA supercoiling is invol ved in the cytotoxic action of these drugs.