ANTIPROLIFERATIVE EFFECT OF TOREMIFENE AND TAMOXIFEN ON ESTROGEN RECEPTOR-LACKING ANAPLASTIC THYROID-CARCINOMA CELL-LINES

Authors
KISHINO T WATANABE M KIMURA M SUGAWARA I
Citation
T. Kishino et al., ANTIPROLIFERATIVE EFFECT OF TOREMIFENE AND TAMOXIFEN ON ESTROGEN RECEPTOR-LACKING ANAPLASTIC THYROID-CARCINOMA CELL-LINES, Biological & pharmaceutical bulletin, 20(12), 1997, pp. 1257-1260
Citations number
23
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
20
Issue
12
Year of publication
1997
Pages
1257 - 1260
Database
ISI
SICI code
0918-6158(1997)20:12<1257:AEOTAT>2.0.ZU;2-I
Abstract
The antitumor effects of toremifene were studied in vitro using 10 ana plastic thyroid carcinoma cell lines and were compared with those of t amoxifen, The antitumor effect of toremifene was dose-dependent and th e IC50 values for these cell lines ranged 20.1-58.5 mu M. Although the cell lines expressed multidrug resistance gene mRNA, multidrug resist ance-associated protein gene mRNA and insulin-like growth factor-1 (IG F-1) receptor mRNA to indicate that toremifene, as well as tamoxifen, is cytolytic at relatively high doses for multidrug-resistant anaplast ic thyroid carcinoma cell lines.