S. Yuki et K. Kogure, THE CHANGES OF LCGU AND RCBF IN THE MCA OCCLUSION-RECIRCULATION MODELIN RATS AND THE AMELIORATING EFFECT OF MCI-186, A NOVEL FREE-RADICAL SCAVENGER, Molecular and chemical neuropathology, 32(1-3), 1997, pp. 123-128
We examined the change of regional cerebral blood flow (rCBF) and loca
l cerebral glucose utilization (LCGU) in the middle cerebral artery (M
CA) occlusion or recirculation model of rats, and tested anti-ischemic
effects of a free radical scavenger, 3-methyl-1-phenyl-pyrazolon-5-on
e (MCl-186). A remarkable increase in LCGU was observed in the cortex
supplied by the anterior cerebral artery after recirculation. This hyp
ermetabolism of glucose was at least partly caused by the postischemic
oxidative injury, since MCl-186 ameliorated the high LCGU in this are
a. These results suggested the usefulness of this type of free radical
scavenger for inhibiting the postischemic injury.