THE CHANGES OF LCGU AND RCBF IN THE MCA OCCLUSION-RECIRCULATION MODELIN RATS AND THE AMELIORATING EFFECT OF MCI-186, A NOVEL FREE-RADICAL SCAVENGER

Authors
YUKI S KOGURE K
Citation
S. Yuki et K. Kogure, THE CHANGES OF LCGU AND RCBF IN THE MCA OCCLUSION-RECIRCULATION MODELIN RATS AND THE AMELIORATING EFFECT OF MCI-186, A NOVEL FREE-RADICAL SCAVENGER, Molecular and chemical neuropathology, 32(1-3), 1997, pp. 123-128
Citations number
17
Categorie Soggetti
Pathology,Neurosciences
Journal title
Molecular and chemical neuropathology → ACNP
ISSN journal
10447393
Volume
32
Issue
1-3
Year of publication
1997
Pages
123 - 128
Database
ISI
SICI code
1044-7393(1997)32:1-3<123:TCOLAR>2.0.ZU;2-4
Abstract
We examined the change of regional cerebral blood flow (rCBF) and loca l cerebral glucose utilization (LCGU) in the middle cerebral artery (M CA) occlusion or recirculation model of rats, and tested anti-ischemic effects of a free radical scavenger, 3-methyl-1-phenyl-pyrazolon-5-on e (MCl-186). A remarkable increase in LCGU was observed in the cortex supplied by the anterior cerebral artery after recirculation. This hyp ermetabolism of glucose was at least partly caused by the postischemic oxidative injury, since MCl-186 ameliorated the high LCGU in this are a. These results suggested the usefulness of this type of free radical scavenger for inhibiting the postischemic injury.