We describe a 42-year-old man with Graves' disease who became thyrotox
ic coincident with a major emotional trauma that was not disclosed unt
il his third visit to the clinic. The possibility that distress denied
might ignite Graves' disease via cross talk in the psychoimmunoendocr
ine network is considered. We suggest that an empathic search for the
stressor that activated the disease and the use of stress reduction te
chniques in the long-term management of Graves' disease may be useful.
If nothing else, the physician may benefit from hearing the story of
the individual's illness rather than the history of a patient's diseas
e.