MAGNESIUM LITHOSPERMATE-B AMELIORATES CISPLATIN-INDUCED INJURY IN CULTURED RENAL EPITHELIAL-CELLS

Authors
YOKOZAWA T DONG EB OURA H NONAKA G NISHIOKA I
Citation
T. Yokozawa et al., MAGNESIUM LITHOSPERMATE-B AMELIORATES CISPLATIN-INDUCED INJURY IN CULTURED RENAL EPITHELIAL-CELLS, Experimental and toxicologic pathology, 49(5), 1997, pp. 343-346
Citations number
20
Journal title
Experimental and toxicologic pathology → ACNP
ISSN journal
09402993
Volume
49
Issue
5
Year of publication
1997
Pages
343 - 346
Database
ISI
SICI code
0940-2993(1997)49:5<343:MLACII>2.0.ZU;2-H
Abstract
A study was conducted to clarify whether magnesium lithospermate B ame liorates cisplatin-induced renal injury in terms of lactate dehydrogen ase and malondialdehyde leakage from LLC-PK1 cells in culture. Magnesi um lithospermate B was shown to suppress the cytotoxicity of cisplatin , the suppressive effect increasing with the dose of magnesium lithosp ermate B.