AN EFFICIENT P-THIOCYANATION OF PHENOLS AND NAPHTHOLS USING A REAGENTCOMBINATION OF PHENYLIODINE DICHLORIDE AND LEAD(II) THIOCYANATE

Authors
KITA Y TAKEDA Y OKUNO T EGI M IIO K KAWAGUCHI K AKAI S
Citation
Y. Kita et al., AN EFFICIENT P-THIOCYANATION OF PHENOLS AND NAPHTHOLS USING A REAGENTCOMBINATION OF PHENYLIODINE DICHLORIDE AND LEAD(II) THIOCYANATE, Chemical and Pharmaceutical Bulletin, 45(12), 1997, pp. 1887-1890
Citations number
30
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
12
Year of publication
1997
Pages
1887 - 1890
Database
ISI
SICI code
0009-2363(1997)45:12<1887:AEPOPA>2.0.ZU;2-B
Abstract
A combination of PhICl2 and Pb(SCN)(2) is effective for the p-selectiv e thiocyanation of various types of p-unsubstituted phenols and naphth ols 1 to give p-thiocyanatophenols and naphthols 3. The reaction proce eded at 0 degrees C to room temperature in good to quantitative yields , Twenty-five examples are given, in which various functional groups, such as chloro, allyl, carbonyl, ester, amide, and primary hydroxyl gr oups, are shown to be compatible with this reaction.