ANTIOXIDATIVE COMPOUNDS ISOLATED FROM SAFFLOWER (CARTHAMUS-TINCTORIUSL.) OIL CAKE

Seven antioxidative serotonin derivatives were isolated from safflower (Carthamus tinctorius L.) oil cake. Their structures were established as N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]ferulamide (1), N-[2-(5-hydrox y-1H-indol-3-yl)ethyl]-p-coumaramide (2), 4,4'-bi-1H-indol-3,3'-yl)die thyl]-di-p-coumaramide (3), N-[2[3'-[2-(p-coumaramido)ethyl]-5,5'-dihy droxy -4,4'-bi-1H-indol-3-yl]ethyl]ferulamide (4), and N,N'-[2,2'-(5,5 '-dihydroxy -4,4'-bi-1H-indol-3,3'-yl)diethyl]-diferulamide (5), -D-gl ucosyloxy)-1H-indol-3-yl)ethyl]-p-conmaranide (6), and beta-D-glucosyl oxy)-1H-indol-3-yl)ethyl]ferulamide (7). Antioxidative activities of t he compounds were measured by the ferric thiocyanate method and the al pha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) method,and compounds 1-5 were found to have relatively strong antioxidative activity.