PREPARATION OF CORE PARTICLES FOR AQUEOUS FILM COATING USING AGITATION FLUIDIZED-BED

Core particles used for aqueous film coating were prepared by agitatio n fluidized bed granulation, and effect of the damping speed on the gr anule properties of mass median diameter, geometric standard deviation , apparent density, yield, friability and specific surface area were i nvestigated, Film coating by an aqueous acrylic copolymer (Eudragit NE -30D) was carried out using the core particles granulated under three levels of damping speeds, and the drug release properties of each coat ed product were identified, Relationship between properties of core pa rticles and the drug release properties were clarified and the optimal granulation conditions to make optimal core particles for film coatin g were determined.