PREPARATION OF USEFUL SYNTHETIC INTERMEDIATES OF TAXOL ANALOGS, CYCLOOCTENONE DERIVATIVES

Authors
YAMADA K TOZAWA T SAITOH K MUKAIYAMA T
Citation
K. Yamada et al., PREPARATION OF USEFUL SYNTHETIC INTERMEDIATES OF TAXOL ANALOGS, CYCLOOCTENONE DERIVATIVES, Chemical and Pharmaceutical Bulletin, 45(12), 1997, pp. 2113-2115
Citations number
10
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
12
Year of publication
1997
Pages
2113 - 2115
Database
ISI
SICI code
0009-2363(1997)45:12<2113:POUSIO>2.0.ZU;2-H
Abstract
Stereoselective syntheses of omega-(alpha-bromoketo) octanals and nona nal with oxygenated functions and formation of the corresponding eight -membered carbocyclic aldols by subsequent samarium(II)-mediated cycli zation are demonstrated. Cyclooctenones deoxygenated at the C2 or C10 position in the taxane framework are prepared by dehydration of the ab ove aldols.