K. Yamada et al., PREPARATION OF USEFUL SYNTHETIC INTERMEDIATES OF TAXOL ANALOGS, CYCLOOCTENONE DERIVATIVES, Chemical and Pharmaceutical Bulletin, 45(12), 1997, pp. 2113-2115
Stereoselective syntheses of omega-(alpha-bromoketo) octanals and nona
nal with oxygenated functions and formation of the corresponding eight
-membered carbocyclic aldols by subsequent samarium(II)-mediated cycli
zation are demonstrated. Cyclooctenones deoxygenated at the C2 or C10
position in the taxane framework are prepared by dehydration of the ab
ove aldols.