THE SACCHAROMYCES-CEREVISIAE CCH1 GENE IS INVOLVED IN CALCIUM INFLUX AND MATING

Authors
FISCHER M SCHNELL N CHATTAWAY J DAVIES P DIXON G SANDERS D
Citation
M. Fischer et al., THE SACCHAROMYCES-CEREVISIAE CCH1 GENE IS INVOLVED IN CALCIUM INFLUX AND MATING, FEBS letters, 419(2-3), 1997, pp. 259-262
Citations number
16
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
419
Issue
2-3
Year of publication
1997
Pages
259 - 262
Database
ISI
SICI code
0014-5793(1997)419:2-3<259:TSCGII>2.0.ZU;2-E
Abstract
The yeast Saccharomyces cerevisiae gene CCH1 (ORF YGR217w) shows high homology with animal calcium channel alpha 1-subunit genes. Knock-out mutants were constructed of Cch1 and of Mid1 which is known to mediate Ca2+ influx in response to the alpha-mating pheromone. Cch1 is involv ed in calcium influx and the late stage of the mating process. The cch 1 mutant sensitivity against the alpha-mating pheromone can be reduced by the addition of extra calcium. The product of this gene is likely to interact with the MID1 gene product in Ca influx or its control. (C ) 1997 Federation of European Biochemical Societies.