The estimation of an individual patient's ''resistance'' to major surg
ery has become an complex matter. Clinical parameters allow risk strat
ification in a large number of patients who are about to undergo nonca
rdiac surgery. Low risk patients can be ''cleared'' for surgery. Moder
ate risk patients should undergo further testing. Exercise testing and
pharmacological stress testing with myocardial perfusion imaging can
refine risk estimation in these patients. This risk stratification is
well backed by scientific data, although most of it is derived from st
udies in the same very high risk population, i.e. patients scheduled f
or vascular surgery. Less hard evidence exists when it comes to the ma
nagement of the high-risk patient. Coronary bypass surgery should prob
ably be reserved for those in whom additional indications for this pro
cedure exist. The perioperative use of beta-blockers can possibly redu
ce operative risk. Data on perioperative monitoring and anesthetic tec
hnique are not yet convincing. The relative merits of various perioper
ative management strategies will remain uncertain until randomised tri
als are performed to evaluate the alternatives systematically.