THE EFFECT OF AMINOGLYCOSIDE-INDUCED ADAPTIVE RESISTANCE ON THE ANTIBACTERIAL ACTIVITY OF OTHER ANTIBIOTICS AGAINST PSEUDOMONAS-AERUGINOSA IN-VITRO

Authors
BARCLAY ML BEGG EJ CHAMBERS ST PEDDIE BA
Citation
Ml. Barclay et al., THE EFFECT OF AMINOGLYCOSIDE-INDUCED ADAPTIVE RESISTANCE ON THE ANTIBACTERIAL ACTIVITY OF OTHER ANTIBIOTICS AGAINST PSEUDOMONAS-AERUGINOSA IN-VITRO, Journal of antimicrobial chemotherapy, 38(5), 1996, pp. 853-858
Citations number
10
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy","Infectious Diseases
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
38
Issue
5
Year of publication
1996
Pages
853 - 858
Database
ISI
SICI code
0305-7453(1996)38:5<853:TEOAAR>2.0.ZU;2-C
Abstract
The effect of gentamicin-induced adaptive resistance on the antibacter ial activity of six non-aminoglycoside antibiotics was studied. Adapti ve resistance was induced in Pseudomonas aeruginosa in a dynamic in-vi tro model of infection. The bactericidal effect of ceftazidime, imipen em, aztreonam, ciprofloxacin, and piperacillin was not altered in the presence of adaptive resistance but the effect of rifampicin was incre ased.