CYTOGENETIC FINDINGS IN 30 LUNG-CARCINOMA PATIENTS

Primary tissue cultures of human lung tumors were prepared from 30 cas es of which 16 rt ere diagnosed as squamous cell carcinoma, three larg e cell carcinoma, and one small cell lung carcinoma. Chromosomal abnor malities were observed in 26 cases by cytogenetic studies with a GTG b anding technique. Specific chromosome bands frequently involved in str uctural abnormalities were seen on 1p11, 1q11, 2p10, 6p10, 7q12, 7q22, 7q32, 8q22, 9q22, 11q11, 21q10, and Xq24. We assumed that especially i(2)(p10), i(9)(p10), i(21)(q10), t(11;12), t(14;15), del(X)(q24), and loss of the Y chromosome may play a role in the development of lung c ancer as secondary changes. In this way, our cytogenetic findings prov ide evidence that multiple genetic lesions are associated with the pat hogenesis of lung cancer. (C) Elsevier Science Inc., 1998.