DETECTION OF A T(8-21)(Q22-Q22) IN A CASE OF M5 ACUTE MONOBLASTIC LEUKEMIA

Authors
MOLERO MT CASARES MTG VALENCIA JM BUENO JL SUAREZ A RUANO A MOLINES A CAMPO C MALCORRA JJ
Citation
Mt. Molero et al., DETECTION OF A T(8-21)(Q22-Q22) IN A CASE OF M5 ACUTE MONOBLASTIC LEUKEMIA, Cancer genetics and cytogenetics, 100(2), 1998, pp. 176-178
Citations number
11
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
100
Issue
2
Year of publication
1998
Pages
176 - 178
Database
ISI
SICI code
0165-4608(1998)100:2<176:DOATIA>2.0.ZU;2-M
Abstract
Although the translocation (8;21) is the single most common structural rearrangement reported in acute myeloblastic leukemia (AML), it is ra rely seen in AML FAB type M5. We describe a case of a 51-year-old male with a diagnosis of acute monoblastic leukemia (AML M5b with hemophag ocytic component) whose karyotype showed at (8;21)(q22;22). To our kno wledge, this is the first report of this translocation in an AML M5b. The t(8:21) has been associated with a good prognosis, but outpatient suffered a fast and fatal evolution. (C) Elsevier Science Inc., 1998.