EFFECTS OF THE ISOCARBACYCLIN METHYL-ESTER CLINPROST INCORPORATED INTO LIPID MICROSPHERES, IN FOCAL ISCHEMIA OF STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS

The effects of TTC-909, the isocarbacyclin methyl ester clinprost (CAS 88931-51-5), incorporated into lipid microspheres, on ischemia-induce d decrease in norepinephrine (NE) contents in stroke-prone spontaneous ly hypertensive rats (SHR-SP) with an occluded middle cerebral aretery (MCA) were examined. Occluding of MCA led to infarction limited to th e cerebral cortex and also a severe decrease in NE contents in periphe ral regions of the infarction. TTC-909 was injected immediately after MCA occlusion, and then daily for 6 consecutive days. As TTC-909 in a dose of 200 ng/kg significantly (p < 0.05) prevented decreases in NE c ontents. TTC-909 may have cytoprotective effects on neuronal damage re lated to ischemia in humans.