EFFECTS OF THE ISOCARBACYCLIN METHYL-ESTER CLINPROST INCORPORATED INTO LIPID MICROSPHERES, IN FOCAL ISCHEMIA OF STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS
T. Yae et al., EFFECTS OF THE ISOCARBACYCLIN METHYL-ESTER CLINPROST INCORPORATED INTO LIPID MICROSPHERES, IN FOCAL ISCHEMIA OF STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS, Arzneimittel-Forschung, 47(11), 1997, pp. 1200-1203
The effects of TTC-909, the isocarbacyclin methyl ester clinprost (CAS
88931-51-5), incorporated into lipid microspheres, on ischemia-induce
d decrease in norepinephrine (NE) contents in stroke-prone spontaneous
ly hypertensive rats (SHR-SP) with an occluded middle cerebral aretery
(MCA) were examined. Occluding of MCA led to infarction limited to th
e cerebral cortex and also a severe decrease in NE contents in periphe
ral regions of the infarction. TTC-909 was injected immediately after
MCA occlusion, and then daily for 6 consecutive days. As TTC-909 in a
dose of 200 ng/kg significantly (p < 0.05) prevented decreases in NE c
ontents. TTC-909 may have cytoprotective effects on neuronal damage re
lated to ischemia in humans.