Ja. Perez et al., N-ARALKYL SUBSTITUTION OF 2-AMINOINDANS - SYNTHESIS AND THEIR INOTROPIC AND CHRONOTROPIC ACTIVITY IN ISOLATED GUINEA-PIG ATRIA, Arzneimittel-Forschung, 47(11), 1997, pp. 1208-1210
Amino substitution of rigid forms of dopamine 4,5-dihydroxy-2-aminoind
an and 5,6-dihydroxy-2-aminoindan with aralkyl functionalities were ca
rried out to investigate the role of such structural modifications upo
n cardiac inotropic-chronotropic activity. Compounds synthesized demon
strated a modest inotropic selectivity, while one of them, described a
s N-[2-(4-hydroxyphenyl)-1-methylethyl]-2-aminoindan hydrobromide 17,
showed a marked inotropic action on isolated heart tissue.