N-ARALKYL SUBSTITUTION OF 2-AMINOINDANS - SYNTHESIS AND THEIR INOTROPIC AND CHRONOTROPIC ACTIVITY IN ISOLATED GUINEA-PIG ATRIA

Citation
Ja. Perez et al., N-ARALKYL SUBSTITUTION OF 2-AMINOINDANS - SYNTHESIS AND THEIR INOTROPIC AND CHRONOTROPIC ACTIVITY IN ISOLATED GUINEA-PIG ATRIA, Arzneimittel-Forschung, 47(11), 1997, pp. 1208-1210
Citations number
12
Journal title
ISSN journal
00044172
Volume
47
Issue
11
Year of publication
1997
Pages
1208 - 1210
Database
ISI
SICI code
0004-4172(1997)47:11<1208:NSO2-S>2.0.ZU;2-Y
Abstract
Amino substitution of rigid forms of dopamine 4,5-dihydroxy-2-aminoind an and 5,6-dihydroxy-2-aminoindan with aralkyl functionalities were ca rried out to investigate the role of such structural modifications upo n cardiac inotropic-chronotropic activity. Compounds synthesized demon strated a modest inotropic selectivity, while one of them, described a s N-[2-(4-hydroxyphenyl)-1-methylethyl]-2-aminoindan hydrobromide 17, showed a marked inotropic action on isolated heart tissue.