In a survey of pathology residents in New York, most of the 69 respond
ents reported adverse reactions to formaldehyde exposure, mostly eye a
nd throat irritation, less often cough and wheezing, and sometimes diz
ziness and drowsiness. A review of the world literature disclosed simi
lar adverse reactions, mainly irritation of the skin, eyes, and upper
respiratory tract and more serious, albeit rare, noxious effects on th
e gastrointestinal and lower respiratory tracts. The causative associa
tion of long-term formaldehyde exposure with cancer in humans is contr
oversial and unproven. Specific actions reduce exposure and minimize t
he effects of exposure to formaldehyde when it occurs.