INDIVIDUAL-DIFFERENCES IN RESPONSE TO IMIPRAMINE IN THE MOUSE TAIL SUSPENSION TEST

The tail suspension test is a behavioural primary screen for detecting potential antidepressant drugs. In this test, a reduction of duration of immobility after treatment with imipramine is obtained in mice of the NMRI strain but not of the CD1 strain. The present experiments evi dence important differences between individuals of the latter strain i n both the amount of immobility observed in naive mice and the effects of three antidepressants. The reproducibility of the tail suspension- induced behavioural despair was high in individual CD1 male mice and a llowed a preselection of spontaneous high and low immobility scorers. Only the high immobility scorers were responsive to imipramine (30 mg/ kg), desipramine (30 mg/kg) and paroxetine (10 mg/kg). The percentage of spontaneous high immobility scorers was higher in NMRI (50%) than i n CD1 (20%) mice, justifying the use of the former strain for screenin g potential antidepressants. However, controlling for individual diffe rences in the spontaneous performance in this animal model of depressi on may provide a useful tool to study behavioural, neurochemical and n euroendocrine correlates of antidepressant action.