SYNTHESIS AND EVALUATION OF A MONOCATIONIC COPPER(II) RADIOPHARMACEUTICAL DERIVED FROM DYLMETHYL)-N'-(SALICYLALDIMINO)-1,3-PROPANEDIAMINE

The monocationic Cu-67 complex of dylmethyl)-N'-(salicylaldimino)-1,3- propanediamine was obtained in high radiochemical purity by reaction o f Cu-67(2+) With the ligand in ethanol solution. Although this compoun d exhibited low heart uptake, the desired myocardial retention was obs erved over the 30 min time period studied in a rat model. Since the oc tanol/water partition coefficient of methyl)-N'-(salicylaldiminato)-1, 3-propanediamine] is lower than a value believed to be the optimal myo cardial uptake, it is likely that derivatives of this compound with a higher lipophilicity merit further investigation for use in myocardial imaging with copper radioisotopes. (C) 1998 Elsevier Science Inc.