Lesions of the orbital apex often present a diagnostic dilemma. Clinic
al assessment and imaging studies are helpful but a tissue biopsy is o
ften required. The morbidity associated with transcranial approaches t
o the orbital apex: may outweigh the benefits of obtaining a biopsy by
these routes. Fine needle aspiration cytology of orbital apex lesions
can be performed bus there are disadvantages with this method. We des
cribe a transnasal endoscopic technique to biopsy the orbital apex. Th
e technique was used successfully to obtain a tissue diagnosis in six
patients with orbital apex lesions. This enabled commencement of defin
itive treatment. There were no significant complications. The transnas
al approach to the orbital apex using the endoscopes is reliable. Endo
scopes provide excellent illumination, magnification, and a panoramic
view of the operative field.