INTRACEREBROVENTRICULAR ANGIOTENSIN-II INCREASES INTRAORAL INTAKE OF WATER IN RATS

Ad lib and intraoral intake tests can separate the effects of drugs on the appetitive and consummatory phases of ingestive behavior. Central angiotensin Il increases ad lib intake from water bottles, but its ef fect on intraoral intake has not been examined. Rats with both lateral intracerebroventricular (ICV) cannulas and intraoral catheters were g iven angiotensin II (100 ng/5 mu l ICV) followed by a 10-min intraoral infusion of water. Angiotensin II increased intraoral intake and incr eased ad Lib water intake from bottles after the intraoral test. Thus angiotensin II increases water intake during both appetitive and consu mmatory phases of drinking. (C) 1998 Elsevier Science Inc.