ALLELIC DELETION AT CHROMOSOME 11P13 DEFINES A TUMOR-SUPPRESSOR REGION BETWEEN THE CATALASE GENE AND D11S935 IN HUMAN NONSMALL CELL LUNG-CARCINOMA

A previous study of 48 primary non-small cell lung carcinomas (NSCLC) for allelic loss at five polymorphic chromosome lip loci indicated reg ions of allelic deletion for both 11p13 and 11p15. To further delineat e the extent of this deletion 28 NSCLCs were examined by high resoluti on deletion mapping for allelic loss at 11p13. 95% (18/28) of the info rmative cases displayed allelic loss at the catalase gene locus (CAT), 64% (18/28) at D11S935 and D11S941E, respectively, and 23% (6/26) at D11S907. The minimal region of deletion is bordered by CAT and D11S935 and spans about 3 cM. The relationship between allelic loss within th is chromosomal region, the presence of a putative predisposition locus and the pathogenetics of NSCLC are discussed.