Borderline personality disorder can be classified into four groups of
symptoms: affective, impulsive, ego-interpersonal, and psychotic. Phar
macotherapy of borderline personality disorder should be directed at t
he severity of the symptoms in each of these groups, rather than by th
e presence or absence of the overall syndrome. This article reviews th
e pharmacotherapy of borderline personality disorder, with special emp
hasis on affective and impulsive symptoms. Overall, the MAOIs, the SSR
Is, and the newer antidepressants (such as venlafaxine) provide the wi
dest spectrum of effective treatment for the symptoms of borderline pe
rsonality disorder.