The consumption of a weak saccharin solution was examined in rats subj
ected to chronic mild stress (CMS). Intake of saccharin was reduced in
stressed animals compared to isolated and group control animals but s
accharin preference was not affected. Removal of water deprivation fro
m the CIMS schedule did not alter the effects of CMS upon saccharin in
take. However, when food deprivation was omitted entirely from the CMS
schedule the reduction in saccharin intake was eliminated. Similarly,
in animals habituated to the full CMS procedure, reduction in sacchar
in intake was abolished by omitting food deprivation or by delaying th
e intake test for 24 h. Both CMS and food deprivation reduced water in
take but had no effect on food consumed during the fluid-intake test.
The presence of food deprivation during CMS appears to be a key factor
affecting saccharin intake. Our data suggest that saccharin intake is
not an appropriate measure of stress and anhedonia.