TOTAL SYNTHESIS OF (+ -)-SCOPADULCIC ACID-B

Authors
OVERMAN LE RICCA DJ TRAN VD
Citation
Le. Overman et al., TOTAL SYNTHESIS OF (+ -)-SCOPADULCIC ACID-B, Journal of the American Chemical Society, 119(50), 1997, pp. 12031-12040
Citations number
62
Journal title
Journal of the American Chemical Society → ACNP
ISSN journal
00027863
Volume
119
Issue
50
Year of publication
1997
Pages
12031 - 12040
Database
ISI
SICI code
0002-7863(1997)119:50<12031:TSO(-A>2.0.ZU;2-J
Abstract
The first total synthesis of a scopadulan diterpene is described. The key step is a double Heck cyclization of dienyl aryl iodide 8 to form tetracyclic enones 24 and 25 in 80-85% combined yield.