NEW ACYLATED SULFOGLYCOLIPIDS AND DIGALACTOLIPIDS AND RELATED KNOWN GLYCOLIPIDS FROM CYANOBACTERIA WITH A POTENTIAL TO INHIBIT THE REVERSE-TRANSCRIPTASE OF HIV-1

Five novel diacylated sulfoglycolipids (1-5) were isolated from the cy anobacterium Scytonema sp. (TAU strain SL-30-1-4) and four novel acyla ted diglycolipids (6-9) were isolated from the cyanobacterium Oscillat oria raoi (TAU strain IL-76-1-2). These two groups of glycolipids and related known glycolipids isolated from these two and three other stra ins of cyanobacteria, Phormidium tenue (TAU strain IL-144-1), O. trich oides (TAU strain IL-104-3-2), and O. limnetica (TAU strain NG-4-1-2), were found to inhibit HIV-1 RT enzymatic activity to different extent s. The structure elucidation of the various compounds is based on the selective hydrolysis of the glycerol ester moieties, GCMS analysis of the methyl ester derivatives of the liberated fatty acids, home-and he teronuclear-2D-NMR techniques, and MS. The use of negative-ion FABMS f or analyzing the combination and distribution of the fatty acids in gl ycolipids is demonstrated.