NORDITERPENOIDS AND DITERPENOIDS FROM SALVIA-MULTICAULIS WITH ANTITUBERCULOUS ACTIVITY

From the roots of Salvia multicaulis, four new aromatic norditerpenoid s, multicaulin (1), 12-demethylmulticauline (2), multiorthoquinone (3) , and 12-demethylmultiorthoquinone (4), two new abietane diterpenoids, 12-methyl-5-dehydrohorminone (5) and 12-methyl-5-dehydroacetylhormino ne (6), as well as a new pimarane diterpenoid, salvipimarone (7), were isolated. Also obtained in this investigation were the known compound s alpha-amyrin, hinokione, horminone, lupeol, manool, 1-oxoferruginol, 18-oxoferruginol, pisiferal, and sempervirol. The structures of compo unds 1-7 were established by 1D and 2D NMR techniques and by chemical methods. The antituberculous activity of 1-7 was tested against Mycoba cterium tuberculosis strain H37Rv, and all compounds were found to be significantly active, with 2 and 4-6 being the most potent substances. Six of these novel compounds were evaluated against a number of addit ional bacterial cultures.