PERFLUOROCARBON EMULSIONS AND OTHER CORPU SCULAR SYSTEMS INFLUENCE ONNEUTROPHIL ACTIVITY

Influence of perfluorodecalin, perfluoromethilcyclohexylpiperidine, pe rfluorotributylamine emulsions on active oxygen form (AOF) generation by neutrophils has been studied. All investigated emulsions stabilized both proxanol 268 and egg yolk phospholipids inhibited PMA-stimulated neutrophil activity. Castor oil emulsion also inhibited the neutrophi l activity. Neutrophil response for chemotactic peptide, was unchanged in the presence of all tested emulsions. We suppose that fast hydroph obic attachment of inert submicrone emulsion particles to cell surface provokes alteration of neutrophil plasma membrane function resulting in a decrease of AOF generation.