THE ACTION OF INSULIN ON CARDIAC CONTRACT ILITY IN ACTIVE, HIBERNATING AND AROUSING GROUND-SQUIRRELS

Authors
NAKIPOVA OV GAINULLIN RZ SAFRONOVA VG KOSARSKY LS BAKANEVA VF IGNATIEV DA AMERKHANOV ZG KOLAEVA SG KUKUSHKIN NI SOLOMONOV NG
Citation
Ov. Nakipova et al., THE ACTION OF INSULIN ON CARDIAC CONTRACT ILITY IN ACTIVE, HIBERNATING AND AROUSING GROUND-SQUIRRELS, Biofizika, 42(6), 1997, pp. 1297-1300
Citations number
16
Journal title
Biofizika → ACNP
ISSN journal
00063029
Volume
42
Issue
6
Year of publication
1997
Pages
1297 - 1300
Database
ISI
SICI code
0006-3029(1997)42:6<1297:TAOIOC>2.0.ZU;2-B
Abstract
During the deep hibernation (at 5-6 degrees C of the heart temperature ) and during arousal from hibernation (at 15-16 degrees C) insulin hav e no effect on contractility. Two opposite inotropic effects of insuli n at concentrations 0,1-50 nM were found at higher temperature of arou sing: a transient positive inotropic effect between 21-28 degrees C, a nd a negative one (about 20-30% from the control value) above 28 degre es C. In active summer and winter animals insulin produced mainly the negative inotropic effect.