SWEETS-SYNDROME IN A SEVERELY NEUTROPENIC PATIENT DURING THERAPY WITHRECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR

We report a new case of Sweet's syndrome (SS) associated with recombin ant human granulocyte colony-stimulating factor (rHuG-CSF) therapy in a patient with acute myelogenous leukemia (AML). The patient developed a fever in association with multiple tender, purpuric and pustular sk in lesions and swelling of both calves after receiving rHuG-CSF 3 mu g /kg/d for 4 days. The absolute neutrophil count was 0.55 x 10(9)/L al onset. A skin biopsy revealed a dense neutrophilic infiltration in the dermis without evidence of vasculitis or infection. All skin and calf lesions regressed within 1 week after prednisolone therapy. Physician s should be aware of potential neutrophil-mediated dermatoses in patie nts with severe neutropenia on rHuG-CSF treatment.