VACCINATION WITH RECOMBINANT VACCINIA VIRUS-VACCINES EXPRESSING GLYCOPROTEIN GENES OF PSEUDORABIES VIRUS IN THE PRESENCE OF MATERNAL IMMUNITY

Piglets which had received colostral antibody to pseudorabie virus (PR V) were divided into four groups and inoculated with a NYVAC vaccinia recombinant expressing glycoprotein go of PRV, a NYVAC recombinant exp ressing glycoprotein gB of PRV, an inactivated PRV vaccine, or no vacc ine. The piglets were vaccinated twice, 3 weeks apart, beginning at ap proximately 2, weeks of age and later challenged with virulent PRV oro nasally. All three vaccines protected similarly when no maternal antib ody was present. Although all three vaccines induced some active immun ity in piglets with maternal antibody, piglets receiving the NYVAC/gB vaccine were the only ones protected similarly whether or not they had maternal antibodies to PRV. (C) 1997 Elsevier Science B.V.