COMPARISON OF MODELS AND DESIGNS FOR OPTIMIZATION OF THE PH AND SOLVENT STRENGTH IN HPLC

Authors
DEAGUIAR PF BOURGUIGNON B MASSART DL
Citation
Pf. Deaguiar et al., COMPARISON OF MODELS AND DESIGNS FOR OPTIMIZATION OF THE PH AND SOLVENT STRENGTH IN HPLC, Analytica chimica acta, 356(1), 1997, pp. 7-17
Citations number
16
Journal title
Analytica chimica acta → ACNP
ISSN journal
00032670
Volume
356
Issue
1
Year of publication
1997
Pages
7 - 17
Database
ISI
SICI code
0003-2670(1997)356:1<7:COMADF>2.0.ZU;2-O
Abstract
Two designs, the one selected with the algorithm of Kennard and Stone and the D-optimal design, and two linear models are compared while opt imising separation in RPLC by varying the pH and the solvent strength of the mobile phase. As a practical example the separation of a mixtur e of beta-blockers is applied. To ease the selection of the number of experiments of a design while applying the algorithm of Kennard and St one, a variant of this algorithm is proposed. (C) 1997 Elsevier Scienc e B.V.