IDENTIFICATION OF THE MOUSE HOMOLOG OF HUMAN DISCS LARGE AND RAT SAP97 GENES

The human homologue of the Drosophila discs large (dlg) tumor suppress or gene encodes a 926 amino acid protein, hDlg, which is a member of t he MAGUK (Membrane Associated GUanylate Kinase homologues) family of p roteins. To facilitate the development of murine model system for func tional studies in vivo, the primary structure of the mouse homologue o f hDlg has been determined. Dlgh1 encodes a similar to 5.5 kb transcri pt that is ubiquitously expressed in murine tissues. Mouse mDlg is a 9 27 amino acid protein that is 95% identical to hDlg and 94% identical to rat synapse associated protein, SAP97. The unusually high conservat ion of the primary structure of murine and human Dlg proteins across t heir distinct protein domains suggests a conserved function in vivo. ( C) 1997 Elsevier Science B.V.