SYNTHESIS AND CELL-GROWTH INHIBITORY PROPERTIES OF SUBSTITUTED (E)-1-PHENYLBUT-1-EN-3-ONES

Authors
DUCKI S HADFIELD JA HEPWORTH LA LAWRENCE NJ LIU CY MCGOWN AT
Citation
S. Ducki et al., SYNTHESIS AND CELL-GROWTH INHIBITORY PROPERTIES OF SUBSTITUTED (E)-1-PHENYLBUT-1-EN-3-ONES, Bioorganic & medicinal chemistry letters, 7(24), 1997, pp. 3091-3094
Citations number
14
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
24
Year of publication
1997
Pages
3091 - 3094
Database
ISI
SICI code
0960-894X(1997)7:24<3091:SACIPO>2.0.ZU;2-J
Abstract
A series of (E)-1-phenylbut-1-en-3-ones, based on the naturally occurr ing (E)-1-(4'-hydroxyphenyl)but-1-en-3-one [IC50 (K562) 60 mu M], was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-1-(Pentafluorophenyl)but-1-en-3-one [IC50 (K 562) 1.8 mu M] was found to be over 30-fold more active than 1. (C) 19 97 Elsevier Science Ltd.