NOVEL CYANOGUANIDINES WITH POTENT ORAL ANTITUMOR-ACTIVITY

Authors
SCHOU C OTTOSEN ER PETERSEN HJ BJORKLING F LATINI S HJARNAA PV BRAMM E BINDERUP L
Citation
C. Schou et al., NOVEL CYANOGUANIDINES WITH POTENT ORAL ANTITUMOR-ACTIVITY, Bioorganic & medicinal chemistry letters, 7(24), 1997, pp. 3095-3100
Citations number
10
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
24
Year of publication
1997
Pages
3095 - 3100
Database
ISI
SICI code
0960-894X(1997)7:24<3095:NCWPOA>2.0.ZU;2-G
Abstract
4-Pyridyl cyanoguanidines with hydrophobic aromatic side chains showed potent antiproliferative activity in the human breast and lung cancer cell lines MCF-7, NYH and H460. In vivo, treatment with N-(6-chloroph enoxyhexyl)-N'-cyano-N ''-4-pyridylguanidine (18, 20 mg/kg/day po.), g ave a complete remission of tumours in a model of NYH inoculated nude mice. (C) 1997 Elsevier Science Ltd.