7-SILYLCAMPTOTHECINS (SILATECANS) - A NEW FAMILY OF CAMPTOTHECIN ANTITUMOR AGENTS

Authors
JOSIEN H BOM D CURRAN DP ZHENG YH CHOU TC
Citation
H. Josien et al., 7-SILYLCAMPTOTHECINS (SILATECANS) - A NEW FAMILY OF CAMPTOTHECIN ANTITUMOR AGENTS, Bioorganic & medicinal chemistry letters, 7(24), 1997, pp. 3189-3194
Citations number
32
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
24
Year of publication
1997
Pages
3189 - 3194
Database
ISI
SICI code
0960-894X(1997)7:24<3189:7(-ANF>2.0.ZU;2-M
Abstract
The synthesis and biological evaluation of about one dozen 7-silylcamp tothecin derivatives are described. Most new compounds show potencies comparable to or better than camptothecin itself. The best compound, 1 1-fluoro-10-amino-7-trimethylsilylcamptothecin, is more than 20 times more potent than camptothecin in cell assays. (C) 1997 Elsevier Scienc e Ltd.